In vivo-like growth of human tumors in vitro.
نویسندگان
چکیده
We show that diverse human tumors obtained directly from surgery or biopsy can grow at high frequency in vitro for long periods of time and still maintain many of their in vivo properties. The in vivo properties maintained in vitro include three-dimensional growth; maintenance of tissue organization and structure, including changes associated with oncogenic transformation; retention of differentiated function; tumorigenicity; and the growth of multiple types of cells from a single tumor.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 83 8 شماره
صفحات -
تاریخ انتشار 1986